Globally, breast cancer accounts for one in four cancer diagnoses; in India, over 100,000 new cases are reported annually. Women with breast cancer often experience high levels of psychological distress, which can diminish their Quality of Life (QoL) and adversely affect clinical outcomes. This study aimed to evaluate the effects of a nurse-led, individualised psychosocial support and nursing care programme on women with breast cancer in India, hypothesising that such an approach could enhance QoL and alleviate psychological distress. The study employed a systematic review and meta-analysis in Phase I to determine the effectiveness of psychosocial interventions, culminating in the development of a tailored PIP. In Phase II, an experimental time-series design was used to assess the effect of the PIP on QoL and psychological distress among 176 women with breast cancer. Using purposive sampling, subjects were assigned to intervention (n=88) and control groups (n=88). The intervention group received PIP, comprising three in-person psycho-education sessions, telephonic follow-ups over three months, and an informational booklet. Pre- and posttest data collection involved the Hospital Anxiety and Depression Scale (HADS), Distress Thermometer, and WHO QoL BREF. Of the 248 identified articles, six studies met the inclusion criteria for qualitative analysis, and four studies qualified for meta- analysis in Phase I. The interventions, particularly psycho-education, demonstrated positive effects on reducing psychological distress at both short-term (6 weeks) and long-term (6 months) follow-ups, with statistical significance in some cases. While the results indicated modest improvements in QoL, especially with cancer-specific QoL measures, the overall clinical impact remained inconclusive. In Phase II, data analysis revealed a significant reduction in psychological distress and improvement in QoL among the intervention group. Key findings included a statistically significant reduction in psychological distress scores in within-group analysis, which further confirmed the intervention effectiveness (Anxiety: F=871.63, p 0.001; Depression: F=1098.33, p 0.001; Distress Thermometer: F=1872.45, p 0.001). QoL scores improved significantly, with within-group F = 472.63, p .0.0001. This study underscores the value of psychosocial interventions tailored to breast cancer patients, demonstrating that PIP effectively reduces psychological distress and enhances QoL, and advocates for developing nurse-led, individualised psychosocial support framework within oncology care in developing regions.