Pregnancy and labour are coupled experiences, an inseparable and invincible phase of every woman life. Individual and environmental factors influence satisfaction in childbirth. The study aimed to identify the effect of holistic nursing interventions on maternal satisfaction about labour among women receiving obstetric care from a selected hospital in Kerala. The framework of the present study was based on Katharine Kolcaba theory of comfort. The research approach was quasi-experimental with a post-test-only comparison group design. The study was conducted at Baby memorial hospital Kozhikode (Kerala) among 164 women with normal vaginal delivery, 80 in the intervention and 84 in the comparison group. The subjects were selected by random sampling of days of two months before and after the intervention from 15 December 2020 to 31 January 2021. Before the intervention, nurses were given training in holistic care during labour. Nurses implemented holistic nursing interventions in the labour room. The data were collected using a patient satisfaction with nursing care quality questionnaire. The study identified a significant increase in maternal satisfaction about labour among women after implementing holistic nursing interventions in the labour room (p 0.001). This study concluded that a holistic nursing approach in intranatal care would benefit women in labour