During the Covid-19 pandemic, like any other pandemic, nursing professionals, along with other healthcare workers, are the pillars of the healthcare system. The World Health Organisation (WHO) declared the Covid-19 outbreak a pandemic in March 2020. Since then, the nurses fighting on the frontline face several challenges, including a critical shortage of nurses, medical supplies, and a variety of mental challenges such as burnout and fear of infection. Our review explores the issues the nurses faced during the Covid-19 crisis. It aims to assess the level of knowledge and to find out the association between the level of knowledge regarding Covid-19 complications among staff nurses working in the Covid-19 care unit in a selected hospital in Ernakulam district. As the disease is evolving, the knowledge of these findings will aid nurses in combating the pandemic with more resilience. The setting of the study was Rajagiri Hospital, Aluva (Kerala). A descriptive research design and the non-probability convenience sampling technique were adopted to collect the data from 30 staff nurses. The tool consisted of a socio-demographic profile and a structured knowledge questionnaire. The quantitative data were analysed using descriptive and inferential statistics. The study results showed that 1 (3.34%) nurse had very good knowledge, 10 (33.33%) had a good level of knowledge and 9 (28.16%) had an average level of knowledge. There is no significant association between knowledge score and selected demographic variables.