Introduction: The nursing profession has traditionally been dominated by females, but in recent years, men have been entering the field. In India, men account for approximately 10-15% of the nursing workforce (Indian Nursing Council, 2021). The objective of the study was to assess the level of professional well-being (work environment, self-esteem and psychological distress) among male nurses. Materials and Methods: Using a descriptive cross-sectional study design, 100 male nurses from selected hospitals provided data via Google Forms and the consecutive sampling method. The tools used for the study were background variables proforma of male nurses, a work environment assessment, a self-esteem scale, and a psychological distress scale. Results: According to the study's findings, half of the male nurses reported having a high level of professional wellbeing (50%) , 61% said their workplace was healthy, 22% had high self-esteem, and half had severe distress (45%). The mean and standard deviation of male nurses' professional well-being were 5.46/15±1.07. A statistically significant positive connection was observed between psychological distress and self-esteem (p < 0.001). Among male nurses, background characteristics such years of experience, type of organization, field of employment, and work environment were statistically significantly correlated (p <0.05). Conclusion: The study presents a conflicting image of male nurses' professional well-being. Even while most participants thought their workplace was healthy and half reported high levels of professional wellbeing, there are still serious concerns. To ensure that male nurses continue to contribute to healthcare, these findings urge aggressive steps to enhance their working conditions and mental health support.