Chronic Kidney Disease (CKD) is a growing public health concern, often managed through haemodialysis, a lifesaving procedure frequently accompanied by painful muscle cramps that impair quality of life. Progressive Muscle Relaxation (PMR), a simple non-pharmacological intervention, may relieve such symptoms, yet its application in CKD care remains underexplored. This quasi-experimental pre-test post-test control group design was conducted among 60 CKD patients receiving haemodialysis at a tertiary care hospital in Gujarat. Participants were equally assigned to experimental and control groups. PMR sessions, guided by the investigator, were administered three times weekly for four weeks. Data were collected using a socio-demographic proforma, Modified Muscle Cramps Questionnaire, and WHOQOL-BREF scale. Preand post-intervention assessments were completed after four weeks, and data were analysed using paired and independent t-tests. During pre-intervention, 67 percent of participants in both groups experienced severe cramps. Post-intervention, severe cramps declined to 27 percent in the experimental group, while 70 percent persisted in the control group. The experimental group’s Quality of Life (QoL) scores improved significantly (pre = 65.4 ± 22.1, post = 114.4 ± 3.9; t = 11.89, p < 0.0001). Between-group comparisons revealed a mean difference of 61.8 (t = 31.78, p < 0.0001), confirming PMR’s positive impact. PMR effectively reduced muscle cramps and enhanced QoL among CKD patients, aligning with previous findings. PMR is a feasible, nurse-led, low-cost intervention that significantly enhances physical comfort and well-being among haemodialysis patients. Integration of PMR into routine dialysis care is recommended to improve holistic outcomes.