Neonates in intensive care frequently undergo painful procedures which, if inadequately managed, may result in immediate physiological stress and potential long-term neurodevelopmental consequences. Pharmacological analgesia is sometimes limited by safety considerations, particularly in pre-term infants, highlighting the importance of nurse-led non-pharmacological interventions. This narrative review of published literature between 2018 and 2025 examines strategies including oral sucrose or sweet solutions, breastfeeding and non-nutritive sucking, skin-to-skin contact (SSC/Kangaroo Mother Care), facilitated tucking and swaddling, and selected sensory approaches. Thirty studies were included randomised controlled trials, cohort studies, and systematic reviews. Across studies, these interventions were generally associated with reductions in behavioural and physiological indicators of procedural pain. Multimodal approaches (eg, sucrose combined with non-nutritive sucking or SSC with breastfeeding) were frequently reported within individual trials to enhance analgesic responses. Oral sucrose was commonly associated with short-term reductions in pain scores, while breastfeeding and SSC offered additional familycentred benefits. Barriers to implementation included staffing constraints, limited standardised protocols, and variability in parental involvement. Facilitators included structured nurse education, institutional support, and active family engagement. While methodological heterogeneity limits direct comparison of interventions, nurse-led nonpharmacological strategies represent feasible and low-risk approaches that support developmentally sensitive and evidence-informed neonatal pain management.